[HTML][HTML] Structural insight into the activation mechanism of human pancreatic prophospholipase A2
Pancreatic phospholipase A2 (phospholipase A2 group 1B, G1B) belongs to the superfamily
of secreted phospholipase A2 (PLA2) enzymes. G1B has been proposed to be a potential
target for diseases such as hypertension, obesity, and diabetes. Human pancreatic
prophospholipase A2 (pro-hG1B) is activated by cleavage of the first seven-residue
propeptide (phospholipase A2 propeptide, PROP). However, questions still remain on the
mode of action for pro-hG1B. In this work, we expressed pro-hG1B in Pichia pastoris and …
of secreted phospholipase A2 (PLA2) enzymes. G1B has been proposed to be a potential
target for diseases such as hypertension, obesity, and diabetes. Human pancreatic
prophospholipase A2 (pro-hG1B) is activated by cleavage of the first seven-residue
propeptide (phospholipase A2 propeptide, PROP). However, questions still remain on the
mode of action for pro-hG1B. In this work, we expressed pro-hG1B in Pichia pastoris and …
