[PDF][PDF] Two HIFs may be better than one
T Seagroves, RS Johnson - Cancer Cell, 2002 - cell.com
Cancer Cell, 2002•cell.com
Two HIFs may be better than one Page 1 CANCER CELL : APRIL 2002 · VOL. 1 · COPYRIGHT
© 2002 CELL PRESS 211 PREVIEWS As they expand, solid tumors can rapidly outgrow the
carrying capacity of the local vasculature; this phenomenon is typically aggravated by the
chaotic vascular structures that form during malignant growth. Thus, tumors are often riddled
with areas of lowered oxygen content, or hypoxia, which has many therapeutic ramifications.
First, hypoxic regions of tumors are much more resistant to radiation, an important problem in …
© 2002 CELL PRESS 211 PREVIEWS As they expand, solid tumors can rapidly outgrow the
carrying capacity of the local vasculature; this phenomenon is typically aggravated by the
chaotic vascular structures that form during malignant growth. Thus, tumors are often riddled
with areas of lowered oxygen content, or hypoxia, which has many therapeutic ramifications.
First, hypoxic regions of tumors are much more resistant to radiation, an important problem in …
Abstract
HIF-2α overexpression directly contributes to renal clear cell tumorigenesis: evidence for HIF as a tumor promoter.
cell.com