Expression of Plasmodium falciparum genes involved in erythrocyte invasion varies among isolates cultured directly from patients
Plasmodium falciparum merozoites invade erythrocytes using a range of alternative ligands
that includes erythrocyte binding antigenic proteins (EBAs) and reticulocyte binding protein
homologues (Rh). Variation in the expression of some of these genes among culture-
adapted parasite lines correlates with the use of different erythrocyte receptors. Here,
expression profiles of four Rh genes and eba175 are analysed in a sample of 42 isolates
cultured from malaria patients in Kenya. The profiles cluster into distinct groups, largely …
that includes erythrocyte binding antigenic proteins (EBAs) and reticulocyte binding protein
homologues (Rh). Variation in the expression of some of these genes among culture-
adapted parasite lines correlates with the use of different erythrocyte receptors. Here,
expression profiles of four Rh genes and eba175 are analysed in a sample of 42 isolates
cultured from malaria patients in Kenya. The profiles cluster into distinct groups, largely …