[HTML][HTML] A common cross-species function for the double epidermal growth factor-like modules of the highly divergent plasmodium surface proteins MSP-1 and MSP-8
An understanding of structural and functional constraints on the C-terminal double
epidermal growth factor (EGF)-like modules of merozoite surface protein (MSP)-1 and
related proteins is of importance to the development of these molecules as malaria vaccines
and drug targets. Using allelic replacement, we show that Plasmodium falciparum parasites
can invade erythrocytes and grow efficiently in the absence of an MSP-1 protein with
authentic MSP-1 EGF domains. In this mutant parasite line, the MSP-1 EGFs were replaced …
epidermal growth factor (EGF)-like modules of merozoite surface protein (MSP)-1 and
related proteins is of importance to the development of these molecules as malaria vaccines
and drug targets. Using allelic replacement, we show that Plasmodium falciparum parasites
can invade erythrocytes and grow efficiently in the absence of an MSP-1 protein with
authentic MSP-1 EGF domains. In this mutant parasite line, the MSP-1 EGFs were replaced …