Most proteins that coat the surface of the extracellular forms of the human malaria parasite
Plasmodium falciparum are attached to the plasma membrane via
glycosylphosphatidylinositol (GPI) anchors. These proteins are exposed to neutralizing
antibodies, and several are advanced vaccine candidates. To identify the GPI-anchored
proteome of P. falciparum we used a combination of proteomic and computational
approaches. Focusing on the clinically relevant blood stage of the life cycle, proteomic …