[HTML][HTML] Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
JS Park, D Svetkauskaite, Q He, JY Kim… - Journal of Biological …, 2004 - ASBMB
High mobility group box 1 (HMGB1) protein, originally described as a DNA-binding protein
that stabilizes nucleosomes and facilitates transcription, can also be released extracellularly
during acute inflammatory responses. Exposure of neutrophils, monocytes, or macrophages
to HMGB1 results in increased nuclear translocation of NF-κB and enhanced expression of
proinflammatory cytokines. Although the receptor for advanced glycation end products
(RAGE) has been shown to interact with HMGB1, other putative HMGB1 receptors are …
that stabilizes nucleosomes and facilitates transcription, can also be released extracellularly
during acute inflammatory responses. Exposure of neutrophils, monocytes, or macrophages
to HMGB1 results in increased nuclear translocation of NF-κB and enhanced expression of
proinflammatory cytokines. Although the receptor for advanced glycation end products
(RAGE) has been shown to interact with HMGB1, other putative HMGB1 receptors are …