[HTML][HTML] An apoptotic signaling pathway in the interferon antiviral response mediated by RNase L and c-Jun NH2-terminal kinase
G Li, Y Xiang, K Sabapathy, RH Silverman - Journal of Biological Chemistry, 2004 - ASBMB
Cellular stress responses induced during viral infections are critical to the health and
survival of organisms. In higher vertebrates, interferons (IFNs) mediate the innate antiviral
response in part through the action of RNase L, a uniquely regulated enzyme. RNase L is
activated by 5′-phosphorylated, 2′-5′ oligoadenylates (2-5A) produced from IFN-
inducible and double stranded RNA-dependent synthetases. We show that viral activation of
the c-Jun NH 2-terminal kinases (JNK) family of MAP kinases and viral induction of …
survival of organisms. In higher vertebrates, interferons (IFNs) mediate the innate antiviral
response in part through the action of RNase L, a uniquely regulated enzyme. RNase L is
activated by 5′-phosphorylated, 2′-5′ oligoadenylates (2-5A) produced from IFN-
inducible and double stranded RNA-dependent synthetases. We show that viral activation of
the c-Jun NH 2-terminal kinases (JNK) family of MAP kinases and viral induction of …