[HTML][HTML] Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent …
A Rammes, J Roth, M Goebeler, M Klempt… - Journal of Biological …, 1997 - ASBMB
Myeloid-related protein (MRP) 8 and MRP14, two members of the S100 family expressed in
myelomonocytic cells, have been ascribed some extracellular functions, eg antimicrobial,
cytostatic, and chemotactic activities. Since S100 proteins lack structural requirements for
secretion via the classical endoplasmic reticulum/Golgi route, the process of secretion is
unclear. We now demonstrate the specific, energy-dependent release of MRP8 and MRP14
by human monocytes after activation of protein kinase C. This secretory process is not …
myelomonocytic cells, have been ascribed some extracellular functions, eg antimicrobial,
cytostatic, and chemotactic activities. Since S100 proteins lack structural requirements for
secretion via the classical endoplasmic reticulum/Golgi route, the process of secretion is
unclear. We now demonstrate the specific, energy-dependent release of MRP8 and MRP14
by human monocytes after activation of protein kinase C. This secretory process is not …