Enteric neuroblasts require the phosphatidylinositol 3-kinase/Akt/Forkhead pathway for GDNF-stimulated survival
S Srinivasan, M Anitha, S Mwangi… - Molecular and Cellular …, 2005 - Elsevier
Glial cell line-derived neurotrophic factor (GDNF)/Ret signaling is required for enteric neural
crest survival, proliferation, migration and process extension, but signaling pathways that
mediate enteric nervous system (ENS) precursor development are poorly understood. We
therefore examined GDNF effects on immunoselected ENS precursor survival and neuronal
process extension in the presence of phosphatidylinositol 3-kinase and mitogen-activated
protein kinase pathway inhibitors. These studies demonstrated that GDNF promotes ENS …
crest survival, proliferation, migration and process extension, but signaling pathways that
mediate enteric nervous system (ENS) precursor development are poorly understood. We
therefore examined GDNF effects on immunoselected ENS precursor survival and neuronal
process extension in the presence of phosphatidylinositol 3-kinase and mitogen-activated
protein kinase pathway inhibitors. These studies demonstrated that GDNF promotes ENS …