Differential neuronal and astrocytic expression of transforming growth factor beta isoforms in rat hippocampus following transient forebrain ischemia
NW Knuckey, P Finch, DE Palm, MJ Primiano… - Molecular brain …, 1996 - Elsevier
Although transforming growth factor-β (TGF-β) is known to be multifunctional in many
physiological systems, its role in the brain is undergoing elucidation. The situation is made
more complex by the presence of multiple isoforms, which may be differentially regulated
and have various activities in each particular cell type. Because neurons are dependent on
neurotrophic factors for survival, we utilized a rat model of transient forebrain ischemia (TFI)
to test the hypothesis that TGF-β isoforms are important in the hippocampal response to …
physiological systems, its role in the brain is undergoing elucidation. The situation is made
more complex by the presence of multiple isoforms, which may be differentially regulated
and have various activities in each particular cell type. Because neurons are dependent on
neurotrophic factors for survival, we utilized a rat model of transient forebrain ischemia (TFI)
to test the hypothesis that TGF-β isoforms are important in the hippocampal response to …