[HTML][HTML] Increased plasma levels of stromal-derived factor-1 (SDF-1/CXCL12) enhance human thrombopoiesis and mobilize human colony-forming cells (CFC) in …
LE Perez, O Alpdogan, JH Shieh, D Wong… - Experimental …, 2004 - Elsevier
OBJECTIVE: Stromal-derived factor-1 (SDF-1/CXCL12) is chemotactic for
lympho/hematopoietic stem cells. We have previously shown that increasing peripheral
blood (PB) levels of SDF-1 with adenovectors expressing human SDF-1 complementary
DNA (ad-SDF-1) leads to hematopoietic stem cell mobilization as well as migration of
megakaryocytes and thrombocytosis in mice. Herein, we studied the in vivo effects of ad-
SDF-1 and of an analogue peptide of SDF-1 (CTCE-0214) on human hematopoiesis in a …
lympho/hematopoietic stem cells. We have previously shown that increasing peripheral
blood (PB) levels of SDF-1 with adenovectors expressing human SDF-1 complementary
DNA (ad-SDF-1) leads to hematopoietic stem cell mobilization as well as migration of
megakaryocytes and thrombocytosis in mice. Herein, we studied the in vivo effects of ad-
SDF-1 and of an analogue peptide of SDF-1 (CTCE-0214) on human hematopoiesis in a …