Tissue-specific muscle, neural and liver stem/progenitor cells reside in the bone marrow, respond to an SDF-1 gradient and are mobilized into peripheral blood during …
M Kucia, J Ratajczak, R Reca… - Blood Cells, Molecules …, 2004 - Elsevier
Several reports imply that bone marrow hematopoietic stem cells transdifferentiate into
tissue-specific stem cells; however, the possibility of committed tissue-specific stem cells pre-
existing in the bone marrow has not been dealt with adequately. We present here an
alternative explanation of the so-called phenomenon of stem cell transdifferentiation. First,
we postulate that tissue-committed stem/progenitor cells circulate in the peripheral blood
and compete for tissue-specific niches. The circulation of these cells plays an important …
tissue-specific stem cells; however, the possibility of committed tissue-specific stem cells pre-
existing in the bone marrow has not been dealt with adequately. We present here an
alternative explanation of the so-called phenomenon of stem cell transdifferentiation. First,
we postulate that tissue-committed stem/progenitor cells circulate in the peripheral blood
and compete for tissue-specific niches. The circulation of these cells plays an important …