[PDF][PDF] Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution
K Hamacher, HH Coenen… - Journal of nuclear …, 1986 - Soc Nuclear Med
K Hamacher, HH Coenen, G Stöcklin
Journal of nuclear medicine, 1986•Soc Nuclear MedAn aminopolyether mediated synthesis of fluorine-18 (1SF) 2-fluoro-2-deoxy-D-
glucose(FOG) has been deVelOped. The nucleophilic fluoiination wiffiaccelerator-
produced[1@ F] fluorideworks at the no-carrier-added level and gives epimericalty pure 2-
1@ FDGwithan uncorrected radiochemical yieldof a maximum 50% ina synthesis time of 50
mm from EOB.
glucose(FOG) has been deVelOped. The nucleophilic fluoiination wiffiaccelerator-
produced[1@ F] fluorideworks at the no-carrier-added level and gives epimericalty pure 2-
1@ FDGwithan uncorrected radiochemical yieldof a maximum 50% ina synthesis time of 50
mm from EOB.
An aminopolyether mediated synthesis of fluorine-18 (1SF) 2-fluoro-2-deoxy-D-glucose(FOG) has been deVelOped. The nucleophilic fluoiination wiffiaccelerator-produced[1@ F] fluorideworks at the no-carrier-added level and gives epimericalty pure 2-1@ FDGwithan uncorrected radiochemical yieldof a maximum 50% ina synthesis time of 50 mm from EOB.
Society of Nuclear Medicine and Molecular Imaging