[HTML][HTML] Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1
D Morse, SE Pischke, Z Zhou, RJ Davis… - Journal of Biological …, 2003 - ASBMB
The stress-inducible protein heme oxygenase-1 provides protection against oxidative stress
and modulates pro-inflammatory cytokines. As the sepsis syndrome results from the release
of pro-inflammatory mediators, we postulated that heme oxygenase-1 and its enzymatic
product CO would protect against lethality in a murine model of sepsis. Mice treated with a
lethal dose of lipopolysaccharide (LPS) and subsequently exposed to inhaled CO had
significantly better survival and lower serum interleukin (IL)-6 and IL-1β levels than their …
and modulates pro-inflammatory cytokines. As the sepsis syndrome results from the release
of pro-inflammatory mediators, we postulated that heme oxygenase-1 and its enzymatic
product CO would protect against lethality in a murine model of sepsis. Mice treated with a
lethal dose of lipopolysaccharide (LPS) and subsequently exposed to inhaled CO had
significantly better survival and lower serum interleukin (IL)-6 and IL-1β levels than their …