Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model
CC Baker, IH Chaudry, HO Gaines, AE Baue - Surgery, 1983 - surgjournal.com
A murine model was used to test the effects of various therapeutic modalities on the rate of
death following intra-abdominal sepsis as produced by cecal ligation and puncture (CLP).
There were no deaths among sham-operated control mice after ether anesthesia, whereas
CLP produced a mortality rate of 100% by 24 hours. When CLP was followed at 16 hours by
excision of the cecum and saline peritoneal lavage (CLPE), the mortality rate was 20% at 24
hours and 60% at 72 hours. The therapeutic modalities consisted of gentamicin (1.5 mg/kg) …
death following intra-abdominal sepsis as produced by cecal ligation and puncture (CLP).
There were no deaths among sham-operated control mice after ether anesthesia, whereas
CLP produced a mortality rate of 100% by 24 hours. When CLP was followed at 16 hours by
excision of the cecum and saline peritoneal lavage (CLPE), the mortality rate was 20% at 24
hours and 60% at 72 hours. The therapeutic modalities consisted of gentamicin (1.5 mg/kg) …