Regulation of plasma triglycerides in insulin resistance and diabetes

HN Ginsberg, YL Zhang, A Hernandez-Ono - Archives of medical research, 2005 - Elsevier
Increased plasma levels of triglycerides (TG) in very low density lipoproteins (VLDL) are not
only common characteristics of the dyslipidemia associated with insulin resistance and type
2 diabetes mellitus (T2DM) but are the central pathophysiologic feature of the abnormal lipid
profile. Overproduction of VLDL leads to increased plasma levels of TG which, via an
exchange process mediated by cholesterol ester transfer protein (CETP), results in low
levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI, and the …