[HTML][HTML] Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78
JN Lee, B Song, RA DeBose-Boyd, J Ye - Journal of Biological Chemistry, 2006 - ASBMB
Insig-1 and Insig-2, closely related endoplasmic reticulum membrane proteins, mediate
transcriptional and post-transcriptional mechanisms that assure cholesterol homeostasis
through their sterol-induced binding to Scap (SREBP cleavage-activating protein) and 3-
hydroxy-3-methylglutaryl coenzyme A reductase. Recent studies show that Insig-1 (but not
Insig-2) is ubiquitinated and rapidly degraded when cells are depleted of sterols.
Conversely, ubiquitination of Insig-1 is blocked, and the protein is stabilized when …
transcriptional and post-transcriptional mechanisms that assure cholesterol homeostasis
through their sterol-induced binding to Scap (SREBP cleavage-activating protein) and 3-
hydroxy-3-methylglutaryl coenzyme A reductase. Recent studies show that Insig-1 (but not
Insig-2) is ubiquitinated and rapidly degraded when cells are depleted of sterols.
Conversely, ubiquitination of Insig-1 is blocked, and the protein is stabilized when …