[HTML][HTML] Microsomal triglyceride transfer protein binding and lipid transfer activities are independent of each other, but both are required for secretion of apolipoprotein …
J Liang, HN Ginsberg - Journal of Biological Chemistry, 2001 - ASBMB
Recent studies indicate that microsomal triglyceride transfer protein (MTP) and
apolipoprotein B (apoB) interact physically via two specific binding sites located within the
amino-terminal globular region of apoB100. The first site is thought to be within the first 5.8%
of the amino-terminal sequence, and the second site is between 9 and 16% of the amino-
terminal sequence. It is not clear from prior studies whether these sites have unique or
overlapping functions. Furthermore, there are no data differentiating between lipid transfer …
apolipoprotein B (apoB) interact physically via two specific binding sites located within the
amino-terminal globular region of apoB100. The first site is thought to be within the first 5.8%
of the amino-terminal sequence, and the second site is between 9 and 16% of the amino-
terminal sequence. It is not clear from prior studies whether these sites have unique or
overlapping functions. Furthermore, there are no data differentiating between lipid transfer …