[HTML][HTML] Mechanisms of glucosamine-induced suppression of the hepatic assembly and secretion of apolipoprotein B-100-containing lipoproteins
W Qiu, RK Avramoglu, AC Rutledge, J Tsai… - Journal of lipid …, 2006 - ASBMB
Glucosamine-induced endoplasmic reticulum (ER) stress was recently shown to specifically
reduce apolipoprotein B-100 (apoB-100) secretion by enhancing the proteasomal
degradation of apoB-100. Here, we examined the mechanisms linking glucosamine-induced
ER stress and apoB-lipoprotein biogenesis. Trypsin sensitivity studies suggested
glucosamine-induced changes in apoB-100 conformation. Endoglycosidase H studies of
newly synthesized apoB-100 revealed glucosamine induced N-linked glycosylation defects …
reduce apolipoprotein B-100 (apoB-100) secretion by enhancing the proteasomal
degradation of apoB-100. Here, we examined the mechanisms linking glucosamine-induced
ER stress and apoB-lipoprotein biogenesis. Trypsin sensitivity studies suggested
glucosamine-induced changes in apoB-100 conformation. Endoglycosidase H studies of
newly synthesized apoB-100 revealed glucosamine induced N-linked glycosylation defects …