Leptin, via leptin receptors (Ob-R), regulates appetite and energy balance. Of the six
isoforms of the receptor identified, so far, only the long form (Ob-Rb) can fully activate
downstream signal transduction pathways. Although the expression and function of leptin
receptors is well described in the adult brain, little is known about the ontogeny of leptin
receptor system around the time of birth. In this study, the mRNA expression patterns of total
leptin receptor, Ob-R, and the long signalling form of the receptor, Ob-Rb, were investigated …