Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels
LJ Shanley, AJ Irving, MG Rae, MLJ Ashford… - nature …, 2002 - nature.com
LJ Shanley, AJ Irving, MG Rae, MLJ Ashford, J Harvey
nature neuroscience, 2002•nature.comLeptin is an important circulating factor that regulates energy balance via the leptin receptor
Ob-Rb in the hypothalamus. Ob-Rb activation may inhibit hypothalamic neurons by
activating ATP-sensitive K+ channels (KATP channels). Here we show that leptin inhibits
hippocampal neurons via phosphoinositide 3-kinase (PI3-kinase)–driven activation of large
conductance, calcium-activated K+ channels (BK channels), but not KATP channels. This
may be an important mechanism for regulating hippocampal excitability.
Ob-Rb in the hypothalamus. Ob-Rb activation may inhibit hypothalamic neurons by
activating ATP-sensitive K+ channels (KATP channels). Here we show that leptin inhibits
hippocampal neurons via phosphoinositide 3-kinase (PI3-kinase)–driven activation of large
conductance, calcium-activated K+ channels (BK channels), but not KATP channels. This
may be an important mechanism for regulating hippocampal excitability.
Abstract
Leptin is an important circulating factor that regulates energy balance via the leptin receptor Ob-Rb in the hypothalamus. Ob-Rb activation may inhibit hypothalamic neurons by activating ATP-sensitive K+ channels (KATP channels). Here we show that leptin inhibits hippocampal neurons via phosphoinositide 3-kinase (PI3-kinase)–driven activation of large conductance, calcium-activated K+ channels (BK channels), but not KATP channels. This may be an important mechanism for regulating hippocampal excitability.
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