Neuroprotective effects of leptin in vivo and in vitro
E Dicou, S Attoub, P Gressens - Neuroreport, 2001 - journals.lww.com
The present study explored the efficacy of leptin in protecting against in vivo induction of
excitotoxic lesions by the glutamatergic analogue ibotenate injected into the developing
mouse brain and against in vitro NMDA-induced cell death in primary neuronal cultures.
Ibotenate injected intracerebrally (ic) to mice on postnatal day 5 produced transcortical
necrosis and white matter cysts. Co-treatment with leptin administered ic or ip reduced
ibotenate-induced cortical lesions and white matter cysts by 50%. in vitro, leptin afforded …
excitotoxic lesions by the glutamatergic analogue ibotenate injected into the developing
mouse brain and against in vitro NMDA-induced cell death in primary neuronal cultures.
Ibotenate injected intracerebrally (ic) to mice on postnatal day 5 produced transcortical
necrosis and white matter cysts. Co-treatment with leptin administered ic or ip reduced
ibotenate-induced cortical lesions and white matter cysts by 50%. in vitro, leptin afforded …