SnapShot: bone metastasis
B Ell, Y Kang - Cell, 2012 - cell.com
SnapShot: Bone Metastasis Page 1 PTHrP HPSE OPN CCL2 VEGF O 2 HIF-1 α VEGF CXCR4
Immune evasion IRF7 α 4 β 1, α V β 3, α 5 β 1 CXCR4 NK cell T cell CXCR4 CXCL12 Integrins
VCAM1 Fibronectin HSC mobilization T umor cell Osteoclast precursor Osteoclast Osteoblast
Hematopoietic stem cell (HSC) RANKL RANK Metastatic niche BONE BONE Bone homing T
umor seeding Hypoxia RANKL CSF-1 MIP-1 α IL-6 IL-8 GM-CSF Jag1 Notch PTHrP MMPs IL-6
Osteolytic metastasis RANKL RANK BMPs IGF1/2 FGF E T -1 WNT1 VEGF PS A Osteoblastic …
Immune evasion IRF7 α 4 β 1, α V β 3, α 5 β 1 CXCR4 NK cell T cell CXCR4 CXCL12 Integrins
VCAM1 Fibronectin HSC mobilization T umor cell Osteoclast precursor Osteoclast Osteoblast
Hematopoietic stem cell (HSC) RANKL RANK Metastatic niche BONE BONE Bone homing T
umor seeding Hypoxia RANKL CSF-1 MIP-1 α IL-6 IL-8 GM-CSF Jag1 Notch PTHrP MMPs IL-6
Osteolytic metastasis RANKL RANK BMPs IGF1/2 FGF E T -1 WNT1 VEGF PS A Osteoblastic …
