The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and …
T Miki, Y Takegami, K Okawa, T Muraguchi… - Journal of biological …, 2007 - ASBMB
The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) is anchored to the cell
surface via glycosylphosphatidylinositol. This molecule antagonizes the function of
membrane type 1 matrix metalloproteinase (MT1-MMP) to promote proMMP-2 maturation.
Here, we attempt to clarify the mechanism underlying RECK functions. First, we found that
RECK forms a complex with MT1-MMP and inhibits its proteolytic activity. Notably, RECK
increases the amount of MT1-MMP that associates with detergent-resistant membranes …
surface via glycosylphosphatidylinositol. This molecule antagonizes the function of
membrane type 1 matrix metalloproteinase (MT1-MMP) to promote proMMP-2 maturation.
Here, we attempt to clarify the mechanism underlying RECK functions. First, we found that
RECK forms a complex with MT1-MMP and inhibits its proteolytic activity. Notably, RECK
increases the amount of MT1-MMP that associates with detergent-resistant membranes …
