Whole blood serotonin and plasma beta-endorphin in autistic probands and their first-degree relatives
M Leboyer, A Philippe, M Bouvard… - Biological …, 1999 - Elsevier
Background: Whole blood serotonin (5-HT) and C-terminally directed β-endorphin protein
immunoreactivity (C-ter-β-EP-ir) are known to be elevated in autistic subjects and might be
possible markers of genetic liability to autism. This study thus investigates the familial
aggregation of 5-HT and of C-ter-β-EP-ir levels in first degree relatives of autistic probands.
Methods: In a sample of 62 autistic subjects and 122 of their first-degree relatives, compared
to age and sex-matched controls, we measured 5-HT by radioenzymology and C-ter-β-EP-ir …
immunoreactivity (C-ter-β-EP-ir) are known to be elevated in autistic subjects and might be
possible markers of genetic liability to autism. This study thus investigates the familial
aggregation of 5-HT and of C-ter-β-EP-ir levels in first degree relatives of autistic probands.
Methods: In a sample of 62 autistic subjects and 122 of their first-degree relatives, compared
to age and sex-matched controls, we measured 5-HT by radioenzymology and C-ter-β-EP-ir …