A double-blind comparison of fluphenazine and haloperidol in outpatient schizophrenic children

DM Engelhardt, P Polizos, J Waizer… - Journal of Autism and …, 1973 - Springer
DM Engelhardt, P Polizos, J Waizer, SP Hoffman
Journal of Autism and Childhood Schizophrenia, 1973Springer
A study is presented in which fluphenazine and haloperidol administered on a double-blind
basis were evaluated in an outpatient group of 30 schizophrenic children, 6 to 12 years of
age. The duration of treatment was 12 weeks. Mean dosage for both treatment groups was
10.4 mg/d, with a maximum dose of 16 mg/d. Both fluphenazine and haloperidol proved
highly effective in our population of schizophrenic children, with the two drugs
indistinguishable in overall efficacy. Both drugs were characterized by low incidence of side …
Abstract
A study is presented in which fluphenazine and haloperidol administered on a double-blind basis were evaluated in an outpatient group of 30 schizophrenic children, 6 to 12 years of age. The duration of treatment was 12 weeks. Mean dosage for both treatment groups was 10.4 mg/d, with a maximum dose of 16 mg/d. Both fluphenazine and haloperidol proved highly effective in our population of schizophrenic children, with the two drugs indistinguishable in overall efficacy. Both drugs were characterized by low incidence of side effects with a tendency for fluphenazine treatment to induce extrapyramidal symptoms with greater frequency than haloperidol. Side effects were easily managed by dose reduction or contramedication. No child had to be terminated due to an adverse reaction. It is suggested that these findings, as well as other reports in the literature, indicate that fluphenazine and haloperidol deserve consideration in the treatment of schizophrenic children.
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