[CITATION][C] The influence of serotonin on crypt cell proliferation in the jejunum of rat
PJM Tutton - Virchows Archiv B, 1974 - Springer
PJM Tutton
Virchows Archiv B, 1974•SpringerThe influence of injected serotonin and of serotonin depletion on crypt cell cycle time and
mitotic time in rat jejunum was studied. Small doses of serotonin (10 μg/kg) were found to
shorten crypt cell cycle time whereas very large doses (300 mg/kg) prolonged both the cell
cycle and mitotic time. Partial serotonin depletion following injection of 6-fluorotryptophan
was also found to retard crypt cell cycle time and mitotic time.
mitotic time in rat jejunum was studied. Small doses of serotonin (10 μg/kg) were found to
shorten crypt cell cycle time whereas very large doses (300 mg/kg) prolonged both the cell
cycle and mitotic time. Partial serotonin depletion following injection of 6-fluorotryptophan
was also found to retard crypt cell cycle time and mitotic time.
Summary
The influence of injected serotonin and of serotonin depletion on crypt cell cycle time and mitotic time in rat jejunum was studied.
Small doses of serotonin (10 μg/kg) were found to shorten crypt cell cycle time whereas very large doses (300 mg/kg) prolonged both the cell cycle and mitotic time. Partial serotonin depletion following injection of 6-fluorotryptophan was also found to retard crypt cell cycle time and mitotic time.
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