A 62‐year‐old Malaysian woman presented with a constellation of skin signs including alopecia, hyperpigmentation and nail dystrophy. On questioning, a history of diarrhoea, taste disturbance and weight loss was found. The onset of these changes coincided with the administration of thyroxine prescribed for a benign multinodular goitre. Hormonal investigations showed no abnormality and no underlying malignancy was found. Investigation of the diarrhoea showed a protein‐losing enteropathy with generalized intestinal polyposis and non‐specific histology. A diagnosis of Cronkhite–Canada syndrome was made. Treatment with prednisone and nutritional support has been partially effective.