PEComa-like Neoplasms Characterized by ASPSCR1-TFE3 Fusion: Another Face of: TFE3:-related Mesenchymal Neoplasia
Identical TFE3-related gene fusions may be found in renal cell carcinoma and mesenchymal
neoplasms such as alveolar soft part sarcoma and TFE3-rearranged perivascular epithelioid
cell tumor (PEComa). Among mesenchymal neoplasms, the ASPSCR1-TFE3 gene fusion
has previously been described only in alveolar soft part sarcoma. We report 3 unusual
mesenchymal neoplasms harboring the ASPSCR1-TFE3 gene fusion, the morphologic
phenotype of which more closely matches PEComa rather than alveolar soft part sarcoma …
neoplasms such as alveolar soft part sarcoma and TFE3-rearranged perivascular epithelioid
cell tumor (PEComa). Among mesenchymal neoplasms, the ASPSCR1-TFE3 gene fusion
has previously been described only in alveolar soft part sarcoma. We report 3 unusual
mesenchymal neoplasms harboring the ASPSCR1-TFE3 gene fusion, the morphologic
phenotype of which more closely matches PEComa rather than alveolar soft part sarcoma …