Aberrant nuclear immunoreactivity for TFE3 in neoplasms with TFE3 gene fusions: a sensitive and specific immunohistochemical assay
P Argani, P Lal, B Hutchinson, MY Lui… - The American journal …, 2003 - journals.lww.com
We report the aberrantly strong nuclear immunoreactivity for the C-terminal portion of TFE3
protein in tumors characterized by chromosome translocations involving the TFE3 gene at
Xp11. 2. This group of tumors includes alveolar soft part sarcoma and a specific subset of
renal carcinomas that tend to affect young patients. They contain fusion genes that encode
chimeric proteins consisting of the N-terminal portion of different translocation partners fused
to the C-terminal portion of TFE3. We postulated that expression of these fusion proteins …
protein in tumors characterized by chromosome translocations involving the TFE3 gene at
Xp11. 2. This group of tumors includes alveolar soft part sarcoma and a specific subset of
renal carcinomas that tend to affect young patients. They contain fusion genes that encode
chimeric proteins consisting of the N-terminal portion of different translocation partners fused
to the C-terminal portion of TFE3. We postulated that expression of these fusion proteins …