Chameleon TFE3-translocation RCC and how gene partners can change morphology: accurate diagnosis using contemporary modalities
MS Tretiakova - Advances in Anatomic Pathology, 2022 - journals.lww.com
Translocation renal cell carcinoma (tRCC) with TFE3 gene rearrangements has been born
as a distinct entity 20 years ago. These relatively rare tumors were notable among other
RCC subtypes because of their disproportionally high incidence among children and young
adults. Initial reports were focused on describing unifying morphologic criteria and typical
clinical presentation. Follow-up studies of ancillary immunohistochemical and hybridization
techniques provided additional diagnostic tools allowing recognition of tRCC tumors in …
as a distinct entity 20 years ago. These relatively rare tumors were notable among other
RCC subtypes because of their disproportionally high incidence among children and young
adults. Initial reports were focused on describing unifying morphologic criteria and typical
clinical presentation. Follow-up studies of ancillary immunohistochemical and hybridization
techniques provided additional diagnostic tools allowing recognition of tRCC tumors in …