[HTML][HTML] The MEF2A isoform is required for striated muscle-specific expression of the insulin-responsive GLUT4 glucose transporter
S Mora, JE Pessin - Journal of Biological Chemistry, 2000 - ASBMB
Previously, we have demonstrated that an MEF2 consensus sequence located between−
473/− 464 in the human GLUT4 gene was essential for both tissue-specific and
hormonal/metabolic regulation of GLUT4 expression (Thai, MV, Guruswamy, S., Cao, KT,
Pessin, JE, and Olson, AL (1998) J. Biol. Chem. 273, 14285–14292). To identify the specific
MEF2 isoform (s) responsible for GLUT4 expression, we studied the pattern of expression of
the MEF2 isoforms in insulin-sensitive tissues. Both heart and skeletal muscle were found to …
473/− 464 in the human GLUT4 gene was essential for both tissue-specific and
hormonal/metabolic regulation of GLUT4 expression (Thai, MV, Guruswamy, S., Cao, KT,
Pessin, JE, and Olson, AL (1998) J. Biol. Chem. 273, 14285–14292). To identify the specific
MEF2 isoform (s) responsible for GLUT4 expression, we studied the pattern of expression of
the MEF2 isoforms in insulin-sensitive tissues. Both heart and skeletal muscle were found to …