[HTML][HTML] Apolipoprotein B production reduces lipotoxic cardiomyopathy: studies in heart-specific lipoprotein lipase transgenic mouse
M Yokoyama, H Yagyu, Y Hu, T Seo, K Hirata… - Journal of Biological …, 2004 - ASBMB
Lipid accumulation is associated with cardiac dysfunction in diabetes and obesity.
Transgenic mice expressing non-transferable lipoprotein lipase (LpL) with a glycosylated
phosphatidyl-inositol (GPI) anchor in cardiomyocytes have dilated cardiomyopathy.
However, the mechanisms responsible for lipid accumulation and cardiomyopathy are not
clear. Hearts from 3-month-old mice expressing GPI-anchored human LpL (hLpL GPI) mice
had increased fatty acid oxidation and heart failure genes and decreased glucose …
Transgenic mice expressing non-transferable lipoprotein lipase (LpL) with a glycosylated
phosphatidyl-inositol (GPI) anchor in cardiomyocytes have dilated cardiomyopathy.
However, the mechanisms responsible for lipid accumulation and cardiomyopathy are not
clear. Hearts from 3-month-old mice expressing GPI-anchored human LpL (hLpL GPI) mice
had increased fatty acid oxidation and heart failure genes and decreased glucose …