[PDF][PDF] Fluid retention mediated by renal PPARγ
B Staels - Cell metabolism, 2005 - cell.com
Cell metabolism, 2005•cell.com
Thiazolidinediones are activators of the nuclear receptor PPARγ with proven efficacy on
glucose homeostasis. However, treatment with these drugs often results in fluid retention
and edema. Recent studies establish a role for PPARγ in renal sodium reabsorption,
providing a mechanism for the plasma volume expansion induced by these drugs.
glucose homeostasis. However, treatment with these drugs often results in fluid retention
and edema. Recent studies establish a role for PPARγ in renal sodium reabsorption,
providing a mechanism for the plasma volume expansion induced by these drugs.
Thiazolidinediones are activators of the nuclear receptor PPARγ with proven efficacy on glucose homeostasis. However, treatment with these drugs often results in fluid retention and edema. Recent studies establish a role for PPARγ in renal sodium reabsorption, providing a mechanism for the plasma volume expansion induced by these drugs.
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