The peroxisome proliferator-activated receptor γ (PPARγ) is abundantly expressed in
adipocytes, and plays an important role in adipocyte differentiation and fat accretion. It is a
heterodimeric partner of the retinoid X receptors α, β and γ, which are also expressed in the
adipose tissue. As lethality of PPARγ−/− and RXRα−/− mouse fetuses precluded the
analysis of PPARγ and RXRα functions in mature adipocytes, we generated RXRαad−/− and
PPARγad−/− mice, in which RXRα and PPARγ are selectively ablated in adult adipocytes …