Renal tubulointerstitial changes after internal irradiation with α-particle–emitting actinium daughters
JS Jaggi, SV Seshan, MR McDevitt… - Journal of the …, 2005 - journals.lww.com
The effect of external γ irradiation on the kidneys is well described. However, the
mechanisms of radiation nephropathy as a consequence of targeted radionuclide therapies
are poorly understood. The functional and morphologic changes were studied
chronologically (from 10 to 40 wk) in mouse kidneys after injection with an actinium-225
(225 Ac) nanogenerator, a molecular-sized, antibody-targeted, in vivo generator of α-particle–
emitting elements. Renal irradiation from free, radioactive daughters of 225 Ac led to time …
mechanisms of radiation nephropathy as a consequence of targeted radionuclide therapies
are poorly understood. The functional and morphologic changes were studied
chronologically (from 10 to 40 wk) in mouse kidneys after injection with an actinium-225
(225 Ac) nanogenerator, a molecular-sized, antibody-targeted, in vivo generator of α-particle–
emitting elements. Renal irradiation from free, radioactive daughters of 225 Ac led to time …